From trouble sleeping to frequent heartburn, the symptoms of acid reflux can cause discomfort, impacting your day-to-day life and your health, too. Many people — about 20% of the U.S. population, according to the National Institutes of Heal

WO2014033366A1 PCT/FI2013/050828 FI2013050828W WO2014033366A1 WO 2014033366 A1 WO2014033366 A1 WO 2014033366A1 FI 2013050828 W FI2013050828 W FI 2013050828W WO 2014033366 A1 WO201

S1†) is a diterpenoid compound isolated from the medicinal plant Anisomeles malabarica7, which we have previously shown to be cytotoxic to oral and cervical cancer cells.8 Recently, we have shown that AA induces apoptosis and cause cell cycle arrest in SiHa cervical Anisomelic acid (AA) is a macrocyclic cembranolide compound extracted from Anisomeles herbal species. Recently, we have shown that AA possesses both anticancer and antiviral activity. However, to date, the plasma protein binding properties of AA are unknown. Here, we describe the molecular interactions of AA with two serum proteins, human serum albumin (HSA) and bovine serum albumin (BSA Anisomelic acid (AA) is one of the principle bioactive compounds isolated from the plant Anisomeles mal - abarica . Recently, we have studied the mode of action of AA-mediated apoptosis Synthesis and evaluation of anisomelic acid like compounds for the treatment of HPV-mediated carcinomas Annual Congress on Medicinal Chemistry, Pharmacology and toxicology July 30 - 31 , 2018 Amsterdam , Netherlands. Rajendran Senthilkumar, Yury Brusentsev, Preethy Paul, Fang Cheng, Maria Sippola-Thiele, Patrik Eklund and John E Eriksson Our earlier research on the cembranoid, anisomelic acid (AA) showed that, AA has the potential to induce apoptosis in HPV cells by the depletion of E6 and E7 oncoproteins. The pharmaceutical composition may comprise Anisomelic acid or salt thereof in an oil-in-water emulsion, for example in an isotropic mixture of at least one oil and at least one surfactant or, alternatively, in a hydrophilic solvent and a co-solvents or surfactant or a combination thereof.

Anisomelic acid

Anisomeles malabarica has been shown to possess Anisomelic Acid, as well as Anisomelolide, Malabaric Acid, 2-Acetoxymalabaric Acid, Anisomelyl Acetate and Anisomelol (Preethy et al. 2013), and essential oils. Anisomelic acid (AA) is a macrocyclic cembranolide compound extracted from Anisomeles herbal species. Recently, we have shown that AA possesses both anti-cancer and anti-viral activity. However The essential oil of the plant is useful in uterine affections (6). The plant yields anisomelic acid, ovatodiolide, 4,7-epoxyovatodiolide, apigenin, terniflorin B, prunin-6”-p-comarate, maslinic acid, hederagenin, and arjunolic acid (6,7).

Novel action modality of the diterpenoid anisomelic acid causes depletion of E6 and E7 viral oncoproteins in HPV-transformed cervical carcinoma cells. CAM, cIAP2, HPV: 5 : 2013: Analysis of the Cytotoxic Potential of Anisomelic Acid Isolated from Anisomeles malabarica.

A pharmaceutical composition for anti-viral cancer treatment in mammals, comprising a therapeutically effective amount of Anisomelic acid or salts thereof. The stereoselective total synthesis of (±)-anisomelic acid (34) has been achieved starting from aldehyde 7, the ozonolysis product of geranyl acetate. Two key steps ensured the stereoselectivity of the synthesis.

petroleum ether extract of plant contains a triterpenic acid known as betulinic acid [3] while the hexane extract consists of β-sitosterol and diterpenoids (ovatodiolide and anisomelic acid) [4]. The aerial parts contain anisomelolide, malabaric acid, 2-acetoxymalabaric acid, anisomelyl acetate, anisomelol and …

Anisomelic acid derivatives as HPV inhibitors. (in col. with Prof. Erikson's team).

Hyaluronic acid is found mostly in your connective tissues, skin and eyes.
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anisomelic acid (I) lobohedleolide (II) (7E)-lobohedleolide (111) The presence of a conjugated acid moiety at Anisomelic acid (AA) (Fig. S1†) is a diterpenoid compound isolated from the medicinal plant Anisomeles malabarica7, which we have previously shown to be cytotoxic to oral and cervical cancer cells.8 Recently, we have shown that AA induces apoptosis and cause cell cycle arrest in SiHa cervical Anisomelic acid (AA) is a macrocyclic cembranolide compound extracted from Anisomeles herbal species. Recently, we have shown that AA possesses both anticancer and antiviral activity. However, to date, the plasma protein binding properties of AA are unknown.

The MTT assay for cell viability indicated that AA is cytotoxic to all of the four cell lines tested in a dose- and duration-dependent manner. Acridine Orange & Ethidium Bromide (AO & EB) and Hoechst 33258 WO2014033366A1 PCT/FI2013/050828 FI2013050828W WO2014033366A1 WO 2014033366 A1 WO2014033366 A1 WO 2014033366A1 FI 2013050828 W FI2013050828 W FI 2013050828W WO 2014033366 A1 WO201 Anisomelic acid (AA) (Fig. S1†) is a diterpenoid compound isolated from the medicinal plant Anisomeles malabarica 7 , which we have previously shown to be cytotoxic to oral and ANISOMELIC-ACID Plant -- -- Wealth of India.
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Senthilkumar R, Brusentsev Y, Paul P, Marimuthu P, Cheng F, Eklund PC & Eriksson JE (2019). Synthesis and Evaluation of Anisomelic acid-like Compounds for the Treatment of HPV-Mediated Carcinomas. Sci Rep. 9:20295. doi: 10.1038/s41598-019-56410-1.

The pharmaceutical composition may comprise Anisomelic acid or salt thereof in an oil-in-water emulsion, for example in an isotropic mixture of at least one oil and at least one surfactant or, alternatively, in a hydrophilic solvent and a Synthesis and Evaluation of Anisomelic acid-like Compounds for the Treatment of HPV-Mediated Carcinomas Rajendran Senthilkumar , Yury Brusentsev , +4 authors J. Eriksson Scientific Reports Anisomelic acid (AA), one of the major compounds in Anisomeles malabarica, was tested for its cytotoxicity and apoptosis-inducing potential in breast and cervical cancer cells. Novel action modality of the diterpenoid anisomelic acid causes depletion of E6 and E7 viral oncoproteins in HPV-transformed cervical carcinoma cells. CAM, cIAP2, HPV: 5 : 2013: Analysis of the Cytotoxic Potential of Anisomelic Acid Isolated from Anisomeles malabarica. A pharmaceutical composition for anti-viral cancer treatment in mammals, comprising a therapeutically effective amount of Anisomelic acid or salts thereof.

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Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect.

Recently, we have studied the mode of action of AA-mediated apoptosis A pharmaceutical composition for anti-viral cancer treatment in mammals, comprising a therapeutically effective amount of Anisomelic acid or salts thereof. The pharmaceutical composition may comprise Anisomelic acid or salt thereof in an oil-in-water emulsion, for example in an isotropic mixture of at least one oil and at least one surfactant or, alternatively, in a hydrophilic solvent and a Synthesis and Evaluation of Anisomelic acid-like Compounds for the Treatment of HPV-Mediated Carcinomas Rajendran Senthilkumar , Yury Brusentsev , +4 authors J. Eriksson Scientific Reports Anisomelic acid (AA), one of the major compounds in Anisomeles malabarica, was tested for its cytotoxicity and apoptosis-inducing potential in breast and cervical cancer cells.